Assessment of Prediction Models for Punch Sticking in Tablet Formulations

Assessment of Prediction Models for Punch Sticking in Tablet Formulations

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Punch sticking SPROUTED PROTEIN CHOC is a common tablet compression manufacturing issue experienced during late-stage large-scale manufacturing.Prediction of punch sticking propensity and identification of the sticking component is important for early-stage formulation development.Application of novel predictive capabilities offers early-stage sticking propensity assessment.16 API compounds were utilised to assess punch sticking prediction using removable punch tip tooling.API descriptors were tested for sticking correlation using multivariate analysis.

NIR imaging, SEM-EDX and Raman microscopy were used Fan Shop - Team Canada - Jerseys to examine the material adhered to the punch tips.Predictive modelling using linear and non-linear equations proved inaccurate in punch sticking mass prediction.PCA analysis identified sticking correlated physical descriptors and provided a dataset and method for further descriptor studies.Raman microscopy was identified as a suitable technique for chemical identification of punch sticking material, which offers insight towards a mechanistic understanding.